{"id":1880,"date":"2018-10-31T11:49:00","date_gmt":"2018-10-31T15:49:00","guid":{"rendered":"https:\/\/nanobiotix.com\/resource\/2018-astro-2018-nbtxr3-in-liver-cancers\/"},"modified":"2024-10-29T08:50:24","modified_gmt":"2024-10-29T12:50:24","slug":"2018-astro-2018-nbtxr3-in-liver-cancers","status":"publish","type":"resource","link":"https:\/\/nanobiotix.com\/fr\/resource\/2018-astro-2018-nbtxr3-in-liver-cancers\/","title":{"rendered":"2018-ASTRO 2018- NBTXR3 in liver cancers"},"content":{"rendered":"

[vc_row padding_top=”0″ padding_bottom=”0″ section_container_layout=”full-width” remove_horizontal_padding=”yes” module_type=”bg-color” gutter_size=”yes” equal_height=”yes” bg_color=”#28282e”][vc_column][vc_row_inner padding_top=”0″ padding_bottom=”0″ gutter_size=”yes” equal_height=”yes”][vc_column_inner column_paddings=”105″ column_position_vertical=”middle” column_min_height=”700″ column_min_height_sm=”400″ column_min_height_xs=”350″ module_type=”bg-image” bg_image=”99″ mask_fx=”yes-mask” mask_color_mode=”palette” mask_bg_color_palette=”main-mask” animation_fx=”yes-animation” animation_delay=”200″ animation_offset_scroll_down=”90″ width=”1\/2″ animation_in=”fadeInUp”][vc_empty_space height=”60px” responsive_lg=”hidden” responsive_md=”hidden”][az_box_icons box_icon_title=”Authors” box_icon_color_mode=”on-the-fly” icon_visibility=”yes-icon” icon_type=”font” icon=”fa fa-edit” icon_color_mode=”on-the-fly” icon_size=”50″ box_icon_color=”#ffffff” icon_color=”#ffffff”]E. Chajon Rodriguez1<\/span>, M. Pracht2<\/span>, T. De Baere3<\/span>, T. V. F. Nguyen4<\/span>, J. P. Bronowicki5<\/span>, V. Vendrely6<\/span>, A. S. Baumann7<\/span>, V. V. Crois\u00e9-Laurent7<\/span>, E. Rio8<\/span>, Y. Rolland9<\/span>, S. Le Sourd9<\/span>, P. Gustin3<\/span>, C. Perret10<\/span>, F. Mornex11<\/span>, D. Peiffert12<\/span>, P. Merle13<\/span>, E. Deutsch14<\/span> 1 – Centre Eug\u00e8ne Marquis – D\u00e9partement de Radioth\u00e9rapie, Rennes, FR 2 – Centre Eugene Marquis, Rennes, FR 3 – Institut Gustave Roussy, Villejuif, FR 4 – Gustave Roussy, Villejuif, FR 5 – INSERM 954, CHU de Nancy, Universit\u00e9 de Lorraine, Nancy, FR 6 – University Hospital of Bordeaux, Bordeaux, FR 7 – Institut de Canc\u00e9rologie de Lorraine, Nancy, FR 8 – Institut de Canc\u00e9rologie de l\u2019Ouest, Nantes, FR 9 – Centre Eug\u00e8ne Marquis, Rennes, FR 10 – Institut de Canc\u00e9rologie de l’Ouest, Nantes, FR 11 – Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, FR 12 – Institut de Canc\u00e9rologie de Lorraine, Vandoeuvre-Les-Nancy, FR 13 – Service d’Hepatogastroent\u00e9rologie, H\u00f4pital de la Croix Rousse, Lyon, FR 14 – Gustave Roussy, Universit\u00e9 Paris-Saclay, Villejuif, FR <\/span>[\/az_box_icons][vc_empty_space height=”60px” responsive_lg=”hidden” responsive_md=”hidden”][\/vc_column_inner][vc_column_inner column_paddings=”105″ column_position_vertical=”middle” module_type=”bg-color” animation_fx=”yes-animation” animation_delay=”300″ animation_offset_scroll_down=”90″ width=”1\/2″ bg_color=”#ffffff” animation_in=”fadeInUp”][vc_empty_space height=”60px” responsive_lg=”hidden” responsive_md=”hidden”][az_box_icons box_icon_title=”Summary” icon_visibility=”yes-icon” icon_type=”font” icon=”az-icon az-icon-layers2″ icon_color_mode=”on-the-fly” icon_color=”#28282e” icon_size=”50″]Radiation oncology technological development is principally focused in improving the precision of radiotherapy (RT) and reducing unwanted irradiation to normal tissues. There is an unmet medical need into ameliorating the energy dose deposit within tumor cells without increasing the dose received by surrounding healthy tissues. In response, hafnium oxide nanoparticles, NBTXR3, were developed. Only when activated by RT, NBTXR3 increases the probability of interaction with incoming radiations to augment the energy dose deposition within tumor cells leading to their death. Their use is particularly relevant in the management of liver cancers, notably hepatocellular carcinoma (HCC) and liver metastasis (mets). This population is heterogenous and difficult to treat due to the presence of underlying liver dysfunction and concomitant malignancies. NBTXR3 activated by stereotactic body radiotherapy (SBRT) is currently evaluated in this population in a phase I\/II study [NCT02721056]. The multidisciplinary aspect of the study, emphasized by the plurality of liver affections, leads physicians from multiple backgrounds to combine their expertise in managing patient\u2019s course. NBTXR3 was well tolerated and comes with a promising safety profile. Recruitment of dose level 22% is ongoing. This study successfully demonstrated the feasibility of a complex multidisciplinary coordination for 2 different important indications in liver oncology.[\/az_box_icons][vc_empty_space height=”60px” responsive_lg=”hidden” responsive_md=”hidden”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_wds_title":"","_wds_metadesc":"","_wds_focus-keywords":"","_wds_meta-robots-adv":"","_wds_meta-robots-noindex":false,"_wds_meta-robots-nofollow":false,"_wds_meta-robots-index":false,"_wds_meta-robots-follow":false,"_wds_autolinks-exclude":false,"_wds_canonical":"","_wds_opengraph":[],"_wds_twitter":[],"wds_primary_resource_type":0,"wds_primary_data_type":0,"wds_primary_indication":0,"wds_primary_platform_type":0,"footnotes":""},"resource_type":[31],"data_type":[25],"indication":[32],"platform_type":[36],"class_list":["post-1880","resource","type-resource","status-publish","hentry","resource_type-abstracts","data_type-clinical","indication-liver","platform_type-nbtxr3"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/resource\/1880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/resource"}],"about":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/types\/resource"}],"version-history":[{"count":0,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/resource\/1880\/revisions"}],"wp:attachment":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/media?parent=1880"}],"wp:term":[{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/resource_type?post=1880"},{"taxonomy":"data_type","embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/data_type?post=1880"},{"taxonomy":"indication","embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/indication?post=1880"},{"taxonomy":"platform_type","embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/platform_type?post=1880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}