{"id":1841,"date":"2018-10-05T12:58:00","date_gmt":"2018-10-05T16:58:00","guid":{"rendered":"https:\/\/nanobiotix.com\/resource\/oncorad-nbxtr3-in-hnscc-and-nsclc-with-anti-pd1\/"},"modified":"2024-10-29T08:50:25","modified_gmt":"2024-10-29T12:50:25","slug":"oncorad-nbxtr3-in-hnscc-and-nsclc-with-anti-pd1","status":"publish","type":"resource","link":"https:\/\/nanobiotix.com\/fr\/resource\/oncorad-nbxtr3-in-hnscc-and-nsclc-with-anti-pd1\/","title":{"rendered":"OncoRad – NBXTR3 in HNSCC and NSCLC with anti-PD1"},"content":{"rendered":"

[vc_row padding_top=”0″ padding_bottom=”0″ section_container_layout=”full-width” remove_horizontal_padding=”yes” module_type=”bg-color” gutter_size=”yes” equal_height=”yes” bg_color=”#28282e”][vc_column][vc_row_inner padding_top=”0″ padding_bottom=”0″ gutter_size=”yes” equal_height=”yes”][vc_column_inner column_paddings=”105″ column_position_vertical=”middle” column_min_height=”700″ column_min_height_sm=”400″ column_min_height_xs=”350″ module_type=”bg-image” bg_image=”99″ mask_fx=”yes-mask” mask_color_mode=”palette” mask_bg_color_palette=”main-mask” animation_fx=”yes-animation” animation_delay=”200″ animation_offset_scroll_down=”90″ width=”1\/2″ animation_in=”fadeInUp”][vc_empty_space height=”60px” responsive_lg=”hidden” responsive_md=”hidden”][az_box_icons box_icon_title=”Authors” box_icon_color_mode=”on-the-fly” icon_visibility=”yes-icon” icon_type=”font” icon=”fa fa-edit” icon_color_mode=”on-the-fly” icon_size=”50″ box_icon_color=”#ffffff” icon_color=”#ffffff”]Seiwert T.1<\/span>, Le Tourneau C.2<\/span>, Paris S.3<\/span>, Bonvalot S.2<\/span> 1 – The University of Chicago Medicine, Chicago (IL), USA 2 – Institut Curie, Paris, France 3 – Nanobiotix, Paris, France <\/span>[\/az_box_icons][vc_empty_space height=”60px” responsive_lg=”hidden” responsive_md=”hidden”][\/vc_column_inner][vc_column_inner column_paddings=”105″ column_position_vertical=”middle” module_type=”bg-color” animation_fx=”yes-animation” animation_delay=”300″ animation_offset_scroll_down=”90″ width=”1\/2″ bg_color=”#ffffff” animation_in=”fadeInUp”][vc_empty_space height=”60px” responsive_lg=”hidden” responsive_md=”hidden”][az_box_icons box_icon_title=”Summary” icon_visibility=”yes-icon” icon_type=”font” icon=”az-icon az-icon-layers2″ icon_color_mode=”on-the-fly” icon_color=”#28282e” icon_size=”50″]Recent clinical studies have demonstrated the efficacy of anti-PD-1<\/em> in recurrent\/metastatic HNSCC<\/em> and upfront metastatic NSCLC<\/em> patients. However, most patients with recurrent\/metastatic HNSCC<\/em> demonstrate innate (primary) resistance to checkpoint inhibition and do not respond to initial therapy and only a subset of metastatic HNSCC\/NSCLC<\/em> patients benefits from this treatment. There is thus an important unmet medical need for a curative treatment of this population. We hypothesized that intra-tumoral\/intralesional injection of NBXTR3 in the tumor or in one metastasis in lung or liver, followed by SABR<\/em> may be a powerful mechanism to convert the local immune microenvironment to a \u201chot\u201d phenotype and thus help to reverse resistance to immune checkpoint inhibition. We thus designed an open label Phase I\/II, non-randomized clinical study of NBTXR3 activated by SABR in combination with approved anti-PD1 in patients with advanced HNSCC<\/em> or NSCLC<\/em>. The primary objective of the phase I is to determine the maximum tolerated dose\/s, the early DLTs and the recom-mended dose\/s of NBTXR3. The primary objectives of the phase II part are complete response of target lesion\/s by RECIST v1.1<\/em> for the locoregional recurrent group, objective Response Rate by RECIST v 1.1<\/em> for the metastatic group and incidence of adverse events in both groups with a complete safety as-sessment.[\/az_box_icons][vc_empty_space height=”60px” responsive_lg=”hidden” 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