{"id":1817,"date":"2014-02-06T13:45:00","date_gmt":"2014-02-06T18:45:00","guid":{"rendered":"https:\/\/nanobiotix.com\/resource\/nbtxr3-concept-and-dose-enhancement-marill-et-al\/"},"modified":"2024-10-29T08:50:30","modified_gmt":"2024-10-29T12:50:30","slug":"nbtxr3-concept-and-dose-enhancement-marill-et-al","status":"publish","type":"resource","link":"https:\/\/nanobiotix.com\/fr\/resource\/nbtxr3-concept-and-dose-enhancement-marill-et-al\/","title":{"rendered":"NBTXR3 concept and dose enhancement &#8211; Marill et al."},"content":{"rendered":"<p>[vc_row padding_top=&#8221;0&#8243; padding_bottom=&#8221;0&#8243; section_container_layout=&#8221;full-width&#8221; remove_horizontal_padding=&#8221;yes&#8221; module_type=&#8221;bg-color&#8221; gutter_size=&#8221;yes&#8221; equal_height=&#8221;yes&#8221; bg_color=&#8221;#28282e&#8221;][vc_column][vc_row_inner padding_top=&#8221;0&#8243; padding_bottom=&#8221;0&#8243; gutter_size=&#8221;yes&#8221; equal_height=&#8221;yes&#8221;][vc_column_inner column_paddings=&#8221;105&#8243; column_position_vertical=&#8221;middle&#8221; column_min_height=&#8221;700&#8243; column_min_height_sm=&#8221;400&#8243; column_min_height_xs=&#8221;350&#8243; module_type=&#8221;bg-image&#8221; bg_image=&#8221;99&#8243; mask_fx=&#8221;yes-mask&#8221; mask_color_mode=&#8221;palette&#8221; mask_bg_color_palette=&#8221;main-mask&#8221; animation_fx=&#8221;yes-animation&#8221; animation_delay=&#8221;200&#8243; animation_offset_scroll_down=&#8221;90&#8243; width=&#8221;1\/2&#8243; animation_in=&#8221;fadeInUp&#8221;][vc_empty_space height=&#8221;60px&#8221; responsive_lg=&#8221;hidden&#8221; responsive_md=&#8221;hidden&#8221;][az_box_icons box_icon_title=&#8221;Authors&#8221; box_icon_color_mode=&#8221;on-the-fly&#8221; icon_visibility=&#8221;yes-icon&#8221; icon_type=&#8221;font&#8221; icon=&#8221;fa fa-edit&#8221; icon_color_mode=&#8221;on-the-fly&#8221; icon_size=&#8221;50&#8243; box_icon_color=&#8221;#ffffff&#8221; icon_color=&#8221;#ffffff&#8221;]Julie Marill<span class=\"notes up\">1<\/span>*, Naeemunnisa Mohamed Anesary<span class=\"notes up\">1<\/span>, Ping Zhang<span class=\"notes up\">1<\/span>, Sonia Vivet<span class=\"notes up\">1<\/span>, Elsa Borghi<span class=\"notes up\">1<\/span>, Laurent Levy<span class=\"notes up\">1<\/span>, Agnes Pottier<span class=\"notes up\">1<\/span> <span class=\"notes\">1 &#8211; Nanobiotix, 60 rue de wattignies, 75012 Paris, France *Corresponding author<\/span>[\/az_box_icons][vc_empty_space height=&#8221;60px&#8221; responsive_lg=&#8221;hidden&#8221; responsive_md=&#8221;hidden&#8221;][\/vc_column_inner][vc_column_inner column_paddings=&#8221;105&#8243; column_position_vertical=&#8221;middle&#8221; module_type=&#8221;bg-color&#8221; animation_fx=&#8221;yes-animation&#8221; animation_delay=&#8221;300&#8243; animation_offset_scroll_down=&#8221;90&#8243; width=&#8221;1\/2&#8243; bg_color=&#8221;#ffffff&#8221; animation_in=&#8221;fadeInUp&#8221;][vc_empty_space height=&#8221;60px&#8221; responsive_lg=&#8221;hidden&#8221; responsive_md=&#8221;hidden&#8221;][az_box_icons box_icon_title=&#8221;Summary&#8221; icon_visibility=&#8221;yes-icon&#8221; icon_type=&#8221;font&#8221; icon=&#8221;az-icon az-icon-layers2&#8243; icon_color_mode=&#8221;on-the-fly&#8221; icon_color=&#8221;#28282e&#8221; icon_size=&#8221;50&#8243;]<strong>Background:<\/strong> Hafnium oxide, NBTXR3 nanoparticles were designed for high dose energy deposition\u00a0within cancer cells when exposed to ionizing radiation. The purpose of this study was to\u00a0assess the possibility of predicting the in vitro the biological effect of NBTXR3 nanoparticles when exposed to ionizing radiation.  <strong>Methods:<\/strong> Cellular uptake of NBTXR3 nanoparticles was assessed in a panel of human cancer cell lines (radioresistant and radiosensitive) by transmission electron microscopy. The radioenhancement of NBTXR3 nanoparticles was measured by the clonogenic survival assay.  <strong>Results:<\/strong> NBTXR3 nanoparticles were taken up by cells in a concentration dependent manner, forming clusters in the cytoplasm. Differential nanoparticle uptake was observed between epithelial and mesenchymal or glioblastoma cell lines. The dose enhancement factor increased with increase NBTXR3 nanoparticle concentration and radiation dose. Beyond a minimum number of clusters per cell, the radioenhancement of NBTXR3 nanoparticles could be\u00a0estimated from the radiation dose delivered and the radiosensitivity of the cancer cell lines.  <strong>Conclusions:<\/strong> Our preliminary results suggest a predictable in vitro biological effect of NBTXR3 nanoparticles exposed to ionizing radiation.[\/az_box_icons][vc_empty_space height=&#8221;60px&#8221; responsive_lg=&#8221;hidden&#8221; responsive_md=&#8221;hidden&#8221;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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