{"id":3286,"date":"2024-11-19T09:46:00","date_gmt":"2024-11-19T14:46:00","guid":{"rendered":"https:\/\/nanobiotix.com\/?page_id=3286"},"modified":"2024-12-12T08:57:42","modified_gmt":"2024-12-12T13:57:42","slug":"curadigm","status":"publish","type":"page","link":"https:\/\/nanobiotix.com\/fr\/our-science\/curadigm\/","title":{"rendered":"Curadigm"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3286\" class=\"elementor elementor-3286\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2fd46ab hero e-flex e-con-boxed e-con e-parent\" data-id=\"2fd46ab\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3415e63 e-flex e-con-boxed e-con e-child\" data-id=\"3415e63\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f156afd elementor-widget elementor-widget-heading\" data-id=\"f156afd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Plateforme Curadigm<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c24dd00 elementor-absolute elementor-widget elementor-widget-image\" data-id=\"c24dd00\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-no-translation=\"\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-c24dd00{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-277f102 elementor-absolute elementor-widget elementor-widget-image\" data-id=\"277f102\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-no-translation=\"\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1821\" height=\"248\" src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/curadigm-type-texture@2x.png\" class=\"attachment-full size-full wp-image-3329\" alt=\"curadigm\" srcset=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/curadigm-type-texture@2x.png 1821w, https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/curadigm-type-texture@2x-768x105.png 768w, https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/curadigm-type-texture@2x-1536x209.png 1536w, https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/curadigm-type-texture@2x-18x2.png 18w\" sizes=\"(max-width: 1821px) 100vw, 1821px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6723955 e-flex e-con-boxed e-con e-parent\" data-id=\"6723955\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3e23c56 e-con-full e-flex e-con e-child\" data-id=\"3e23c56\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5049de1 elementor-widget elementor-widget-heading\" data-id=\"5049de1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Red\u00e9finir la conception et le d\u00e9veloppement des m\u00e9dicaments pour exploiter pleinement les possibilit\u00e9s des th\u00e9rapies de nouvelle g\u00e9n\u00e9ration<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-02ce1b1 e-con-full e-flex e-con e-child\" data-id=\"02ce1b1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bfa096a elementor-widget elementor-widget-text-editor\" data-id=\"bfa096a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dans toute maladie trait\u00e9e, la biodisponibilit\u00e9 syst\u00e9mique des m\u00e9dicaments \u2013 qui correspond \u00e0 leur -temps de circulation dans le sang permettant l'accumulation de l'agent th\u00e9rapeutique dans le tissu cible pour d\u00e9livrer le traitement \u2013 est essentielle \u00e0 l\u2019efficacit\u00e9 th\u00e9rapeutique.<sup>1<\/sup> Toutefois, pour atteindre sa concentration maximale dans le tissu cible, un m\u00e9dicament doit surmonter un obstacle biologique de taille : l\u2019organisme lui-m\u00eame.<\/p><p>Le r\u00f4le du foie est d\u2019\u00e9liminer les compos\u00e9s du sang, dont un grand nombre de m\u00e9dicaments. Ainsi, de nombreux candidats th\u00e9rapeutiques prometteurs administr\u00e9s par voie intraveineuse pr\u00e9sentent une biodisponibilit\u00e9 faible ou suboptimale, qui se traduit par une accumulation faible ou nulle dans les tissus cibles et par une toxicit\u00e9 hors cible potentiellement \u00e9lev\u00e9e.<sup>2<\/sup> Par cons\u00e9quent, si beaucoup de m\u00e9dicaments pr\u00e9sentent un potentiel \u00e0 l\u2019\u00e9chelle du laboratoire, la plupart n\u2019ont pas d\u2019avenir clinique.<\/p><p>Pour surmonter cet obstacle, nous avons d\u00e9velopp\u00e9 la plateforme  Curadigm. Le nanoprimer est  con\u00e7u pour augmenter de fa\u00e7on temporaire la biodisponibilit\u00e9 des th\u00e9rapies administr\u00e9es par voie intraveineuse et pour minimiser le risque d\u2019effets en dehors de la cible. Ce concept, <em>first-in-class<\/em>, pourrait permettre d'\u00e9liminater de l'une des barri\u00e8res biologiques majeures limitant l'acc\u00e8s \u00e0 la clinique de certaines agents th\u00e9rapeutiques prometteurs, tels que les m\u00e9dicaments \u00e0 base d\u2019ARN\/ADN, ou les virus oncolytiques, entre autres. De plus, en r\u00e9glant le probl\u00e8me de la clairance dans le foie, il serait permis d\u2019avoir une action plus efficace des m\u00e9dicaments d\u00e9j\u00e0 autoris\u00e9s, et donc assurer de meilleurs r\u00e9sultats th\u00e9rapeutiques pour les patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ecfe71 e-con-full e-flex e-con e-child\" data-id=\"7ecfe71\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3e84bd8 elementor-widget elementor-widget-video\" data-id=\"3e84bd8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=bke8CNvd_DA&quot;,&quot;yt_privacy&quot;:&quot;yes&quot;,&quot;lazy_load&quot;:&quot;yes&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a927559 light-background e-flex e-con-boxed e-con e-parent\" data-id=\"a927559\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a5bdb32 elementor-widget elementor-widget-text-editor\" data-id=\"a5bdb32\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Plateforme Curadigm : Diminuer la clairance h\u00e9patique pour mieux d\u00e9livrer le traitement dans le tissu cible<\/h2><p>Compos\u00e9s de nanoparticules lipidiques fabriqu\u00e9es avec pr\u00e9cision, le nanoprimer est destin\u00e9 \u00e0 occuper temporairement les voies h\u00e9patiques responsables de la clairance th\u00e9rapeutique, afin de permettre \u00e0 un m\u00e9dicament donn\u00e9 de plus fortement s\u2019accumuler dans des tissus cibles, tout en minimisant le risque de toxicit\u00e9 h\u00e9patique chez le patient.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbd2adb elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"dbd2adb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-dbd2adb{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec38e4f elementor-hidden-widescreen elementor-hidden-desktop elementor-hidden-laptop elementor-hidden-tablet_extra elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"ec38e4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-ec38e4f{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bcd11c1 elementor-widget elementor-widget-image\" data-id=\"bcd11c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/12\/curadigm-solution-mobile-outline1210-FR.svg\" class=\"attachment-large size-large wp-image-3628 lazyload\" alt=\"curadigm solution\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a4cfc3a e-flex e-con-boxed e-con e-parent\" data-id=\"a4cfc3a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ac4678 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"7ac4678\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Principaux avantages de la plateforme Curadigm<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5610662 e-con-full quote-name e-flex e-con e-child\" data-id=\"5610662\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-047ce6a elementor-widget elementor-widget-image\" data-id=\"047ce6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"146\" height=\"113\" data-src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/icon-increase.svg\" class=\"attachment-full size-full wp-image-3402 lazyload\" alt=\"icon - increase\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 146px; --smush-placeholder-aspect-ratio: 146\/113;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e50301 no-bot-margin elementor-widget elementor-widget-text-editor\" data-id=\"5e50301\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"reg-text\">01<\/span><br \/>Augmente temporairement la biodisponibilit\u00e9 syst\u00e9mique<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6fff5f7 e-con-full quote-name e-flex e-con e-child\" data-id=\"6fff5f7\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dd268d9 elementor-widget elementor-widget-image\" data-id=\"dd268d9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/icon-uncouple.svg\" class=\"attachment-full size-full wp-image-3403 lazyload\" alt=\"icon - uncouple\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16050b4 no-bot-margin elementor-widget elementor-widget-text-editor\" data-id=\"16050b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"reg-text\">02<\/span><br \/>Dissocie la biodisponibilit\u00e9 et l\u2019administration th\u00e9rapeutique en deux objets independants, ce qui permet d\u2019optimiser les autres fonctions du m\u00e9dicament<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-32144c6 e-con-full quote-name e-flex e-con e-child\" data-id=\"32144c6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1a49463 elementor-widget elementor-widget-image\" data-id=\"1a49463\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"123\" height=\"94\" data-src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/icon-do-not.svg\" class=\"attachment-full size-full wp-image-3404 lazyload\" alt=\"icon - do not\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 123px; --smush-placeholder-aspect-ratio: 123\/94;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9cccd36 no-bot-margin elementor-widget elementor-widget-text-editor\" data-id=\"9cccd36\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"reg-text\">03<\/span><br \/>Le m\u00e9canisme d\u2019action du Nanoprimer est bas\u00e9 sur ses propri\u00e9t\u00e9s physico-chimique uniquement. Il ne contient pas de substances actives   ou de produits biologiques additionnels pour occuper les cellules h\u00e9patiques et ne d\u00e9clenche pas de r\u00e9action immunitaire<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b583d60 e-flex e-con-boxed e-con e-parent\" data-id=\"b583d60\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ed76fdf elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"ed76fdf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Maximise le potentiel th\u00e9rapeutique<\/h2><p>Notre objectif est de nous associer \u00e0 des entreprises qui, comme nous, cherchent \u00e0 supprimer l\u2019obstacle de la biodisponibilit\u00e9 et\/ou de l\u2019h\u00e9patotoxicit\u00e9 qui compromettent l\u2019utilit\u00e9 clinique de th\u00e9rapies pourtant prometteuses.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-be8ec40 e-con-full e-flex e-con e-child\" data-id=\"be8ec40\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e989cea text-22 elementor-widget elementor-widget-heading\" data-id=\"e989cea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Notre plateforme de nanoprimers s\u2019applique dans de multiples indications et classes th\u00e9rapeutiques administr\u00e9es par voie intraveineuse.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b40637e elementor-widget__width-inherit bold-weight-text elementor-widget elementor-widget-heading\" data-id=\"b40637e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Classes th\u00e9rapeutiques<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c71e134 no-bot-margin elementor-widget elementor-widget-text-editor\" data-id=\"c71e134\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Nanom\u00e9dicaments avec encapsulation de petites mol\u00e9cules<br \/>Acide nucl\u00e9ique (ARN et ADN)<br \/>Outil d\u2019\u00e9dition g\u00e9n\u00e9tique<br \/>Conjugu\u00e9s anticorps-m\u00e9dicaments<br \/>Virus oncolytiques<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b43694 elementor-widget__width-inherit bold-weight-text elementor-widget elementor-widget-heading\" data-id=\"2b43694\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Domaines th\u00e9rapeutiques<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9134d2 elementor-widget elementor-widget-text-editor\" data-id=\"e9134d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Oncologie<br \/>Maladies rares<br \/>Maladies infectieuses<br \/>Maladies du syst\u00e8me nerveux central<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1a1b41e e-con-full e-flex e-con e-child\" data-id=\"1a1b41e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fce6183 elementor-widget elementor-widget-image\" data-id=\"fce6183\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"594\" height=\"732\" data-src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/img-curadigm-glyph-image.png\" class=\"attachment-large size-large wp-image-3406 lazyload\" alt=\"curadigm image\" data-srcset=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/img-curadigm-glyph-image.png 594w, https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/img-curadigm-glyph-image-10x12.png 10w\" data-sizes=\"auto\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 594px; --smush-placeholder-aspect-ratio: 594\/732;\" data-original-sizes=\"(max-width: 594px) 100vw, 594px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-334c200 e-flex e-con-boxed e-con e-parent\" data-id=\"334c200\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5f5c885 legal-text no-bot-margin elementor-widget elementor-widget-text-editor\" data-id=\"5f5c885\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>References: 1. Stielow, Marlena &amp; Witczy\u0144ska, Adrianna &amp; Kubry\u0144, Natalia &amp; Fija\u0142kowski, \u0141ukasz &amp; Nowaczyk, Jacek &amp; Nowaczyk, Alicja. (2023). The Bioavailability of Drugs\u2014The Current State of Knowledge. Molecules. 28. 8038. 10.3390\/molecules28248038. 2. Lautt WW. Hepatic Circulation: Physiology and Pathophysiology. San Rafael (CA): Morgan &amp; Claypool Life Sciences; 2009. Chapter 12, Hepatic Circulation and Toxicology. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK53072\/<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Curadigm Nanoprimer Platform Disrupting drug design and development to unleash the power of innovative therapies No matter the disease being treated, drug bioavailability \u2014 the extent to which a drug enters systemic circulation and accesses the targeted tissues \u2014 is critical for therapeutic efficacy.1 However, in order for a drug to reach the maximally effective [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":28,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-3286","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/pages\/3286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/comments?post=3286"}],"version-history":[{"count":0,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/pages\/3286\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/pages\/28"}],"wp:attachment":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/media?parent=3286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}