{"id":3096,"date":"2024-11-15T12:50:39","date_gmt":"2024-11-15T17:50:39","guid":{"rendered":"https:\/\/nanobiotix.com\/?page_id=3096"},"modified":"2025-06-06T09:49:09","modified_gmt":"2025-06-06T13:49:09","slug":"nbtxr3","status":"publish","type":"page","link":"https:\/\/nanobiotix.com\/fr\/our-science\/nbtxr3\/","title":{"rendered":"NBTXR3"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3096\" class=\"elementor elementor-3096\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3e01b0d hero e-flex e-con-boxed e-con e-parent\" data-id=\"3e01b0d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3e44945 e-flex e-con-boxed e-con e-child\" data-id=\"3e44945\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c733198 elementor-widget elementor-widget-heading\" data-id=\"c733198\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Platforme de Nanoradioenhancer<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b12212 elementor-absolute elementor-widget elementor-widget-image\" data-id=\"6b12212\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-no-translation=\"\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-6b12212{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b9e6fc elementor-absolute elementor-widget elementor-widget-image\" data-id=\"4b9e6fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-no-translation=\"\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"808\" height=\"124\" src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/nbtxr3-type-texture.png\" class=\"attachment-full size-full wp-image-3247\" alt=\"NBTXR3\" srcset=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/nbtxr3-type-texture.png 808w, https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/nbtxr3-type-texture-768x118.png 768w, https:\/\/nanobiotix.com\/wp-content\/uploads\/2024\/11\/nbtxr3-type-texture-18x3.png 18w\" sizes=\"(max-width: 808px) 100vw, 808px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a2ac9c1 e-flex e-con-boxed e-con e-parent\" data-id=\"a2ac9c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0427c28 e-con-full e-flex e-con e-child\" data-id=\"0427c28\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f9e15ab elementor-widget elementor-widget-heading\" data-id=\"f9e15ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Une nouvelle \u00e8re th\u00e9rapeutique pour des millions de personnes atteintes d\u2019un cancer<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7aba730 elementor-widget elementor-widget-text-editor\" data-id=\"7aba730\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La plupart des personnes atteintes d\u2019un cancer n\u00e9cessitant un traitement souffrent d\u2019une maladie locale (c\u2019est-\u00e0-dire, d\u2019une seule tumeur primaire) au moment du diagnostic, ou bien ont suivi un traitement pour une maladie locale, mais celui-ci s\u2019est av\u00e9r\u00e9 inefficace. Les personnes atteintes d\u2019une maladie m\u00e9tastatique (c\u2019est-\u00e0-dire, une maladie dans laquelle des tumeurs se sont propag\u00e9es au-del\u00e0 de la tumeur primaire) sont moins nombreuses.<\/p><p>La radioth\u00e9rapie est le traitement le plus largement r\u00e9pandu dans la prise en charge des personnes atteintes d\u2019un cancer local ou d\u2019un cancer local et m\u00e9tastatique, et concerne chaque ann\u00e9e 12 millions de nouveaux patients dans le monde.<sup>1<\/sup> Associ\u00e9e \u00e0 d\u2019autres th\u00e9rapies telles que la chirurgie, la chimioth\u00e9rapie ou les th\u00e9rapies cibl\u00e9es, elle donne des r\u00e9sultats positifs chez de nombreux patients. Toutefois, malgr\u00e9 les avanc\u00e9es technologiques qui augmentent l\u2019efficacit\u00e9 de l\u2019irradiation dans des zones sp\u00e9cifiques et bien d\u00e9finies, des l\u00e9sions des tissus normaux restent in\u00e9vitables aux doses requises pour une radiation efficace.<sup>2<\/sup> Par cons\u00e9quent, l\u2019efficacit\u00e9 du traitement par radioth\u00e9rapie reste limit\u00e9e par la dose qui peut \u00eatre administr\u00e9e.<sup>2<\/sup><\/p><p>Le nanoradioenhancer <em>first-in-class<\/em> NBTXR3 est con\u00e7u pour augmenter la dose de radioth\u00e9rapie absorb\u00e9e et d\u00e9pos\u00e9e \u00e0 l\u2019int\u00e9rieur des cellules tumorales sans accro\u00eetre la dose dans les tissus sains environnants, d\u00e9truisant ainsi la tumeur cible et amor\u00e7ant la r\u00e9ponse immunitaire sur les tumeurs m\u00e9tastatiques. En augmentant de mani\u00e8re significative le potentiel de destruction tumorale de la radioth\u00e9rapie sans augmenter les l\u00e9sions des tissus sains, NBTXR3 est une r\u00e9ponse potentielle aux besoins de millions de personnes atteintes d\u2019un cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-15dd9d5 light-background e-flex e-con-boxed e-con e-parent\" data-id=\"15dd9d5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1d81537 e-con-full e-flex e-con e-child\" data-id=\"1d81537\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fbb339e elementor-widget elementor-widget-heading\" data-id=\"fbb339e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Une int\u00e9gration parfaite au paysage th\u00e9rapeutique existant<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-138fb7e elementor-widget elementor-widget-text-editor\" data-id=\"138fb7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>NBTXR3 est con\u00e7u pour augmenter de mani\u00e8re significative l\u2019\u00e9nergie d\u00e9pos\u00e9e par la radioth\u00e9rapie \u00e0 l\u2019int\u00e9rieur des cellules tumorales afin d\u2019induire une mort cellulaire tumorale significative sans augmenter les dommages caus\u00e9s aux tissus sains environnants.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6dded13 e-con-full icons-w-bars e-flex e-con e-child\" data-id=\"6dded13\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-28fcf6c elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"28fcf6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">NBTXR3 en bref <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-116ffcf e-con-full e-flex e-con e-child\" data-id=\"116ffcf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb6a44c elementor-widget__width-initial elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"cb6a44c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"admin\" width=\"72\" height=\"83.8\" viewbox=\"0 0 72 83.8\"><defs><clippath id=\"needle\"><path d=\"M36,0C55.9,0,72,27.9,72,47.8s-16.1,36-36,36S0,67.7,0,47.8,16.1,0,36,0Z\" style=\"fill: none;\"><\/path><\/clippath><\/defs><circle cx=\"36\" cy=\"47.8\" r=\"36\" style=\"fill: none;\"><\/circle><circle cx=\"36\" cy=\"47.8\" r=\"34.2\" style=\"fill: none; stroke: #000; stroke-width: 3.5px;\"><\/circle><g id=\"need-group\"><g style=\"clip-path: url(#needle);\"><g id=\"syringe\"><path id=\"Path_34416\" d=\"M28.2,103.1c.5.5.5,1.3,0,1.8-.2.2-.5.4-.9.4h-7.9c-.7,0-1.2-.6-1.2-1.2s.6-1.2,1.2-1.2h7.9c.3,0,.6.1.9.4Z\" style=\"stroke: #000; stroke-width: .5px;\"><\/path><path id=\"Path_34417\" d=\"M28.2,91.5c.5.5.5,1.3,0,1.8-.2.2-.5.4-.9.4h-7.9c-.7,0-1.2-.6-1.2-1.2,0-.7.6-1.2,1.2-1.2h7.9c.3,0,.6.1.9.4Z\" style=\"stroke: #000; stroke-width: .5px;\"><\/path><path id=\"Path_34418\" d=\"M28.2,79.9c.5.5.5,1.3,0,1.8-.2.2-.5.4-.9.4h-7.9c-.7,0-1.2-.6-1.2-1.2,0-.7.6-1.2,1.2-1.2h7.9c.3,0,.6.1.9.4Z\" style=\"stroke: #000; stroke-width: .5px;\"><\/path><path id=\"Path_34419\" d=\"M28.2,65.3c.5.5.5,1.3,0,1.8-.2.2-.5.4-.9.4h-7.9c-.7,0-1.2-.6-1.2-1.2,0-.7.6-1.2,1.2-1.2h7.9c.3,0,.6.1.9.4Z\" style=\"stroke: #000; stroke-width: .5px;\"><\/path><path id=\"Path_34437\" d=\"M28.2,72.3c.5.5.5,1.3,0,1.8-.2.2-.5.4-.9.4h-7.9c-.7,0-1.2-.6-1.2-1.2,0-.7.6-1.2,1.2-1.2h7.9c.3,0,.6.1.9.4Z\" style=\"stroke: #000; stroke-width: .5px;\"><\/path><path id=\"Path_34420\" d=\"M43.1,46.6c.5.5.5,1.3,0,1.8-.2.2-.5.4-.9.4h-12.4c-.7,0-1.2-.6-1.2-1.2,0-.7.6-1.2,1.2-1.2h12.4c.3,0,.6.1.9.4Z\" style=\"stroke: #000; stroke-width: .5px;\"><\/path><path id=\"Path_34421\" d=\"M36.9,2.2c.2.3.4.7.4,1.1v35.3c.2.7-.3,1.4-.9,1.5-.7.2-1.4-.3-1.5-.9,0-.2,0-.4,0-.6V3.4c0-.8.5-1.5,1.2-1.6.3,0,.7.2.9.5Z\" style=\"stroke: #000; stroke-width: .5px;\"><\/path><path id=\"Path_34422\" d=\"M28.5,39v8.7c0,2.6-1.4,4.9-3.6,6.1-4.2,2.2-6.7,6.6-6.7,11.3v48.9h2.5v-48.9c0-3.8,2.1-7.3,5.4-9.1,3-1.7,4.9-4.9,4.9-8.3v-7.4h10v7.4c0,2.5,1,4.9,2.8,6.7.6.6,1.4,1.2,2.2,1.6,3.4,1.8,5.4,5.3,5.4,9.1v48.9h2.5v-48.9c0-4.7-2.6-9.1-6.7-11.3-2.2-1.2-3.6-3.6-3.6-6.1v-8.7c0-.7-.6-1.2-1.2-1.2h-12.4c-.7,0-1.2.6-1.2,1.2h0Z\" style=\"stroke: #000; stroke-width: .5px;\"><\/path><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tAdministration\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c510b75 elementor-widget__width-initial elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"c510b75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"freq\" width=\"72\" height=\"72\" viewbox=\"0 0 72 72\"><path d=\"M15.7,48.9v-4.8h7.5v-18.7h-.4l-5.7,7.4-3.8-3,6.7-8.8h9.2v23.1h5.9v4.8s-19.4,0-19.4,0Z\"><\/path><path d=\"M36.7,48.9l6.9-10.7-6.8-10.3h6.7l3.9,6.6h.2l3.8-6.6h6.2l-7,10.5,7,10.5h-6.7l-4-6.8h-.2l-3.9,6.8h-6.2,0Z\"><\/path><g id=\"Ellipse_524\"><circle cx=\"36\" cy=\"36\" r=\"36\" style=\"fill: none;\"><\/circle><path d=\"M36,72C16.1,72,0,55.9,0,36S16.1,0,36,0s36,16.1,36,36-16.1,36-36,36ZM36,3.5C18.1,3.5,3.5,18.1,3.5,36s14.6,32.5,32.5,32.5,32.5-14.6,32.5-32.5S53.9,3.5,36,3.5Z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tFr\u00e9quence\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b962950 no-bot-margin elementor-widget elementor-widget-text-editor\" data-id=\"b962950\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Administr\u00e9 par une injection unique directement dans une tumeur maligne avant une radioth\u00e9rapie ionisante conventionnelle<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc0b21d e-con-full e-flex e-con e-child\" data-id=\"cc0b21d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6080f6f elementor-widget__width-initial elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"6080f6f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"scale\" width=\"72\" height=\"72\" viewbox=\"0 0 72 72\"><path d=\"M16.6,32.8l-3.1,3.1,2,2.3h0c0-.3-.2-.5-.2-.8v-.6c0-.2,0-.4.2-.6.1-.2.3-.4.5-.6.3-.3.6-.5,1-.7s.7-.2,1.1-.2.8,0,1.1.2c.4.2.8.4,1.1.8.4.4.6.7.8,1.1s.3.8.3,1.3-.1.9-.3,1.3c-.2.5-.5.9-.9,1.3s-.7.6-1,.8-.7.3-1,.4-.6,0-.9,0c-.3,0-.6,0-.9,0l.2-1.9c.4,0,.8.2,1.2,0,.4,0,.8-.2,1.1-.6s.5-.7.5-1.1-.2-.7-.5-1.1h0c-.3-.4-.7-.6-1-.6s-.7.2-1,.5-.4.5-.5.8v.7l-1.4,1-3.7-4.2,4.2-4.2,1.3,1.3-.2.3Z\"><\/path><path d=\"M26.1,34.8c-.9.9-1.9,1.3-3,1.1s-2.2-.9-3.3-2c-1.1-1.1-1.8-2.2-2-3.3s.2-2,1.1-3c.9-.9,1.9-1.3,2.9-1.1s2.2.9,3.3,2c1.1,1.1,1.8,2.2,2,3.3.2,1.1-.2,2-1.1,3h.1ZM24.8,33.6c.4-.4.5-.8.4-1.3-.1-.4-.5-.9-1-1.5l-1.3-1.3c-.5-.5-1-.9-1.5-1-.4-.1-.9,0-1.3.4s-.5.8-.4,1.3.5.9,1,1.5l1.3,1.3c.5.5,1,.9,1.5,1s.9,0,1.3-.4Z\"><\/path><path d=\"M29.6,31l-5.2-5.2,1.5-1.5.9.9h0c-.2-.4-.3-.8-.2-1.2,0-.4.3-.8.7-1.3s1.1-.8,1.7-.7c.6,0,1.3.5,1.9,1.1l3.3,3.3-1.5,1.5-3.1-3.1c-.3-.3-.6-.5-.9-.6s-.5,0-.8.3-.2.2-.3.4c0,.1-.1.3-.2.4v.5c0,.1.1.3.3.4l3.4,3.4-1.5,1.5h0Z\"><\/path><path d=\"M35.5,25.1l-5.2-5.2,1.5-1.5.9.9h0c-.2-.4-.3-.8-.2-1.2,0-.4.2-.8.6-1.2.4-.4.7-.6,1.2-.6s.9,0,1.3.2h0c0-.2-.2-.4-.2-.7v-.7c0-.2,0-.5.2-.7,0-.2.3-.4.5-.6.5-.5,1.1-.7,1.7-.6.6,0,1.3.5,1.9,1.1l3.3,3.3-1.5,1.5-3.1-3.1c-.7-.7-1.2-.8-1.7-.3-.2.2-.4.5-.4.8s0,.6.3.8l3.4,3.4-1.5,1.5-3.1-3.1c-.7-.7-1.2-.8-1.7-.3,0,.1-.2.2-.3.4,0,.1,0,.3,0,.4v.4c0,.1,0,.3.3.4l3.4,3.4-1.5,1.5v-.2Z\"><\/path><path d=\"M36,72C16.1,72,0,55.9,0,36S16.1,0,36,0s36,16.1,36,36-16.1,36-36,36ZM36,3.5C18.1,3.5,3.5,18.1,3.5,36s14.6,32.5,32.5,32.5,32.5-14.6,32.5-32.5S53.9,3.5,36,3.5Z\"><\/path><path d=\"M56.7,13.3h-7.9c-.8,0-1.5.7-1.5,1.5s.2.8.4,1.1.7.4,1.1.4h4.4s-.2.1-.2.2L16.2,53.2v-4.4c0-.4-.2-.8-.4-1.1-.6-.6-1.5-.6-2.1,0s-.4.7-.4,1.1v7.9c0,.8.7,1.5,1.5,1.5h7.9c.8,0,1.5-.7,1.5-1.5s-.7-1.5-1.5-1.5h-4.3L55,18.6s.2-.2.2-.3v4.3c0,.4.2.8.4,1.1.3.3.7.4,1.1.4s.8-.1,1.1-.4.4-.7.4-1.1v-7.9c0-.8-.7-1.5-1.5-1.5h0Z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tEchelle\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30d47b7 elementor-widget__width-initial elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"30d47b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"hoc\" width=\"72\" height=\"72\" viewbox=\"0 0 72 72\"><g id=\"Ellipse_475\"><circle cx=\"36\" cy=\"36\" r=\"36\" style=\"fill: none;\"><\/circle><path d=\"M36,72C16.1,72,0,55.9,0,36S16.1,0,36,0s36,16.1,36,36-16.1,36-36,36ZM36,3.5C18.1,3.5,3.5,18.1,3.5,36s14.6,32.5,32.5,32.5,32.5-14.6,32.5-32.5S53.9,3.5,36,3.5Z\"><\/path><\/g><g id=\"Ellipse_476\"><circle cx=\"36\" cy=\"36\" r=\"4\" style=\"fill: none;\"><\/circle><path d=\"M36,40c-2.2,0-4-1.8-4-4s1.8-4,4-4,4,1.8,4,4-1.8,4-4,4ZM36,34.5c-.8,0-1.5.7-1.5,1.5s.7,1.5,1.5,1.5,1.5-.7,1.5-1.5-.7-1.5-1.5-1.5Z\"><\/path><\/g><circle id=\"Ellipse_477\" cx=\"36\" cy=\"28\" r=\"2\"><\/circle><circle id=\"Ellipse_513\" cx=\"36\" cy=\"18\" r=\"2\"><\/circle><circle id=\"Ellipse_494\" cx=\"32.6\" cy=\"23.4\" r=\"2\"><\/circle><circle id=\"Ellipse_501\" cx=\"24.7\" cy=\"29.5\" r=\"2\"><\/circle><circle id=\"Ellipse_506\" cx=\"23.1\" cy=\"34.2\" r=\"2\"><\/circle><circle id=\"Ellipse_480\" cx=\"32\" cy=\"29.1\" r=\"2\"><\/circle><circle id=\"Ellipse_518\" cx=\"25.3\" cy=\"24.2\" r=\"2\"><\/circle><circle id=\"Ellipse_482\" cx=\"29.1\" cy=\"32\" r=\"2\"><\/circle><circle id=\"Ellipse_484\" cx=\"28\" cy=\"36\" r=\"2\"><\/circle><circle id=\"Ellipse_514\" cx=\"20\" cy=\"42\" r=\"2\"><\/circle><circle id=\"Ellipse_521\" cx=\"14\" cy=\"29\" r=\"2\"><\/circle><circle id=\"Ellipse_507\" cx=\"25.6\" cy=\"43.8\" r=\"2\"><\/circle><circle id=\"Ellipse_502\" cx=\"29.5\" cy=\"47.3\" r=\"2\"><\/circle><circle id=\"Ellipse_520\" cx=\"32.2\" cy=\"57.1\" r=\"2\"><\/circle><circle id=\"Ellipse_508\" cx=\"34.2\" cy=\"48.9\" r=\"2\"><\/circle><circle id=\"Ellipse_486\" cx=\"29.1\" cy=\"40\" r=\"2\"><\/circle><circle id=\"Ellipse_488\" cx=\"32\" cy=\"42.9\" r=\"2\"><\/circle><circle id=\"Ellipse_478\" cx=\"36\" cy=\"44\" r=\"2\"><\/circle><circle id=\"Ellipse_509\" cx=\"43.8\" cy=\"46.4\" r=\"2\"><\/circle><circle id=\"Ellipse_503\" cx=\"47.3\" cy=\"42.5\" r=\"2\"><\/circle><circle id=\"Ellipse_510\" cx=\"48.9\" cy=\"37.8\" r=\"2\"><\/circle><circle id=\"Ellipse_479\" cx=\"40\" cy=\"42.9\" r=\"2\"><\/circle><circle id=\"Ellipse_515\" cx=\"41.8\" cy=\"51.6\" r=\"2\"><\/circle><circle id=\"Ellipse_481\" cx=\"42.9\" cy=\"40\" r=\"2\"><\/circle><circle id=\"Ellipse_483\" cx=\"44\" cy=\"36\" r=\"2\"><\/circle><circle id=\"Ellipse_516\" cx=\"54\" cy=\"36\" r=\"2\"><\/circle><circle id=\"Ellipse_511\" cx=\"46.4\" cy=\"28.2\" r=\"2\"><\/circle><circle id=\"Ellipse_504\" cx=\"42.5\" cy=\"24.7\" r=\"2\"><\/circle><circle id=\"Ellipse_512\" cx=\"37.8\" cy=\"23.1\" r=\"2\"><\/circle><circle id=\"Ellipse_485\" cx=\"42.9\" cy=\"32\" r=\"2\"><\/circle><circle id=\"Ellipse_487\" cx=\"40\" cy=\"29.1\" r=\"2\"><\/circle><circle id=\"Ellipse_517\" cx=\"52.7\" cy=\"31\" r=\"2\"><\/circle><circle id=\"Ellipse_519\" cx=\"50\" cy=\"18.1\" r=\"2\"><\/circle><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tHafnium Oxide Core\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3bde7b1 no-bot-margin elementor-widget elementor-widget-text-editor\" data-id=\"3bde7b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>NBTXR3 poss\u00e8de des propri\u00e9t\u00e9s physiques uniques qui permettent une accumulation locale plus importante du rayonnement dans les cellules canc\u00e9reuses<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-de29271 elementor-widget elementor-widget-text-editor\" data-id=\"de29271\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>D\u00e8s son activation, NBTXR3 augmente jusqu\u2019\u00e0 9 fois l\u2019\u00e9nergie d\u00e9pos\u00e9e par la radioth\u00e9rapie dans les cellules tumorales inject\u00e9es, par rapport \u00e0 un traitement par radioth\u00e9rapie seule.<sup>3<\/sup> Les donn\u00e9es cliniques sugg\u00e8rent que le m\u00e9canisme d\u2019action de NBTXR3 entra\u00eene par la suite une destruction importante des cellules tumorales sans aggravation des dommages caus\u00e9s aux tissus sains environnants.<sup>4<\/sup> Dans la mesure o\u00f9 les nanoparticules NBTXR3 reviennent \u00e0 leur \u00e9tat inactif apr\u00e8s chaque exposition aux rayonnements, il est possible d\u2019administrer plusieurs traitements de radioth\u00e9rapie \u00e0 une tumeur apr\u00e8s une injection unique de NBTXR3.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-849c94d e-flex e-con-boxed e-con e-child\" data-id=\"849c94d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8b681c3 elementor-widget elementor-widget-video\" data-id=\"8b681c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=-c2Y8kLWmq8&quot;,&quot;yt_privacy&quot;:&quot;yes&quot;,&quot;lazy_load&quot;:&quot;yes&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-19c72c5 light-background e-flex e-con-boxed e-con e-parent\" data-id=\"19c72c5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-23ea134 e-con-full e-flex e-con e-child\" data-id=\"23ea134\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2a447c2 elementor-widget elementor-widget-heading\" data-id=\"2a447c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Implications en immuno-oncologie<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-941bad3 no-bot-margin elementor-widget elementor-widget-text-editor\" data-id=\"941bad3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Les premi\u00e8res donn\u00e9es cliniques sugg\u00e8rent que NBTXR3 activ\u00e9 par radioth\u00e9rapie pourrait rendre les cellules canc\u00e9reuses plus visibles pour le syst\u00e8me immunitaire et amorcer la r\u00e9ponse immunitaire de l\u2019organisme. Nous pensons que cela peut se produire de plusieurs mani\u00e8res. Un m\u00e9canisme implique la lib\u00e9ration de mod\u00e8les mol\u00e9culaires associ\u00e9s aux dommages qui sont reconnus par les cellules immunitaires comme un signe de stress ou de blessure cellulaire.<sup>5<\/sup> Une r\u00e9ponse immunitaire contre la tumeur primaire et les cellules m\u00e9tastatiques peut alors \u00eatre d\u00e9clench\u00e9e en raison de la mort cellulaire immunog\u00e8ne, \u00e0 savoir un type de mort cellulaire qui entra\u00eene l\u2019activation du syst\u00e8me immunitaire. En outre, des \u00e9tudes ont montr\u00e9 la capacit\u00e9 de NBTXR3 \u00e0 augmenter l\u2019expression des prot\u00e9ines de surface cellulaire qui am\u00e9liorent la pr\u00e9sentation des antig\u00e8nes tumoraux aux cellules immunitaires, avec comme cons\u00e9quence possible une de la reconnaissance et de la destruction des cellules canc\u00e9reuses.<sup>6<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6460239 elementor-widget elementor-widget-button\" data-id=\"6460239\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/clinicaltrials.gov\/search?term=NBTXR3&#038;aggFilters=status:rec%20not\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Notre Pipeline <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e41991a e-flex e-con-boxed e-con e-parent\" data-id=\"e41991a\" data-element_type=\"container\" data-e-type=\"container\" id=\"NBTXR3_head_neck\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-67aadc3 e-con-full e-flex e-con e-child\" data-id=\"67aadc3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-78a07df elementor-widget elementor-widget-heading\" data-id=\"78a07df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">NBTXR3 dans le carcinome \u00e9pidermo\u00efde de la t\u00eate et du cou (HNSCC)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6980d0e elementor-widget elementor-widget-text-editor\" data-id=\"6980d0e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">Le HNSCC se situe au sixi\u00e8me rang des tumeurs malignes les plus fr\u00e9quentes dans le monde, et 40 % des patients touch\u00e9s sont des personnes de 70 ans ou plus. En raison de leur fragilit\u00e9 li\u00e9e \u00e0 de multiples comorbidit\u00e9s, ces patients ne peuvent recevoir des traitements agressifs.<sup>7<\/sup> Devant l\u2019urgence de trouver des th\u00e9rapies plus efficaces et mieux tol\u00e9r\u00e9es, adapt\u00e9es \u00e0 ces patients particuli\u00e8rement vuln\u00e9rables, Nanobiotix a choisi d\u2019\u00e9valuer la tol\u00e9rance et l\u2019efficacit\u00e9 de NBTXR3 activ\u00e9 par radioth\u00e9rapie dans cette population vuln\u00e9rable.<\/p><p>En 2019, la FDA am\u00e9ricaine a d\u00e9livr\u00e9 la d\u00e9signation Fast Track pour l\u2019\u00e9tude de NBTXR3 activ\u00e9 par radioth\u00e9rapie associ\u00e9e ou non au Cetuximab chez les patients atteints de HNSCC localement avanc\u00e9 qui n\u2019\u00e9taient pas \u00e9ligibles \u00e0 la chimioth\u00e9rapie \u00e0 base de platine.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-793494d e-con-full e-flex e-con e-child\" data-id=\"793494d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b64b4f4 elementor-widget elementor-widget-image\" data-id=\"b64b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"548\" data-src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2023\/06\/img_post_it_Injection.jpg\" class=\"attachment-full size-full wp-image-829 lazyload\" alt=\"Post injection intra-tumorale\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 640px; --smush-placeholder-aspect-ratio: 640\/548;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5fba47 med-text elementor-widget elementor-widget-heading\" data-id=\"f5fba47\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">Post injection intra-tumorale<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70bd126 e-con-full e-flex e-con e-child\" data-id=\"70bd126\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1d643d3 elementor-widget elementor-widget-image\" data-id=\"1d643d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"548\" data-src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2023\/06\/img_post_radiotherapy.jpg\" class=\"attachment-full size-full wp-image-830 lazyload\" alt=\"\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 640px; --smush-placeholder-aspect-ratio: 640\/548;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-429c605 med-text elementor-widget elementor-widget-heading\" data-id=\"429c605\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">Post radioth\u00e9rapie<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6e9e6e6 e-con-full e-flex e-con e-child\" data-id=\"6e9e6e6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-853e395 elementor-widget elementor-widget-image\" data-id=\"853e395\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"548\" data-src=\"https:\/\/nanobiotix.com\/wp-content\/uploads\/2023\/06\/img_7_months_after_radiotherapy.jpg\" class=\"attachment-full size-full wp-image-828 lazyload\" alt=\"7 mois apr\u00e8s le traitement par radioth\u00e9rapie\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 640px; --smush-placeholder-aspect-ratio: 640\/548;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e924680 med-text elementor-widget elementor-widget-heading\" data-id=\"e924680\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">7 mois apr\u00e8s le traitement par radioth\u00e9rapie<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-853bd9d elementor-widget elementor-widget-text-editor\" data-id=\"853bd9d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Les r\u00e9sultats pr\u00e9liminaires positifs d'un essai de phase 1 d'escalade de dose et d'expansion de dose sugg\u00e8rent que NBTXR3 pourrait am\u00e9liorer les r\u00e9sultats du traitement chez les patients atteints de HNSCC et pourrait devenir une option th\u00e9rapeutique importante, en particulier pour les patients vuln\u00e9rables qui ne sont pas candidats \u00e0 d'autres traitements. Un essai d'enregistrement mondial de phase 3 \u00e9valuant NBTXR3 dans cette population est actuellement en cours.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70d7e30 elementor-widget elementor-widget-button\" data-id=\"70d7e30\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/nanobiotix.com\/fr\/media-publications\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Nos recherches<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-36c132b light-background e-flex e-con-boxed e-con e-parent\" data-id=\"36c132b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-48cf7f7 e-con-full e-flex e-con e-child\" data-id=\"48cf7f7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ec7b012 elementor-widget elementor-widget-heading\" data-id=\"ec7b012\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Vers un radioenhancer au mode d\u2019action universel<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d43b59 elementor-widget elementor-widget-text-editor\" data-id=\"6d43b59\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Le m\u00e9canisme d\u2019action de NBTXR3 repose sur la physique et non sur la biologie ou la chimie. Par cons\u00e9quent, nous estimons que ses effets pourront \u00eatre \u00e9tendus \u00e0 un large spectre de tumeurs solides et de voies de traitement. Dans un essai clinique de phase 2\/3 portant sur 176 patients atteints de sarcome des tissus mous, les patients trait\u00e9s avec NBTXR3 en association avec une radioth\u00e9rapie ont enregistr\u00e9 des taux de r\u00e9ponse pathologique compl\u00e8te significativement plus \u00e9lev\u00e9e que le groupe ayant re\u00e7u la radioth\u00e9rapie seule.8 Combin\u00e9es \u00e0 des donn\u00e9es sur des stades pr\u00e9coces \u00e0 tardifs dans plusieurs indications, dont les cancers de la t\u00eate et du cou, le cancer du foie et le cancer du pancr\u00e9as, ces donn\u00e9es indiquent que NBTXR3, activ\u00e9 par radioth\u00e9rapie, pourrait fournir une nouvelle option de traitement pour tout un spectre de tumeurs solides, utilis\u00e9 seul ou en association avec d\u2019autres th\u00e9rapies.<sup>8<\/sup> Combin\u00e9es \u00e0 des donn\u00e9es sur des stades pr\u00e9coces \u00e0 tardifs dans plusieurs indications, dont les cancers de la t\u00eate et du cou, le cancer du foie et le cancer du pancr\u00e9as, ces donn\u00e9es indiquent que NBTXR3, activ\u00e9 par radioth\u00e9rapie, pourrait fournir une nouvelle option de traitement pour tout un spectre de tumeurs solides, utilis\u00e9 seul ou en association avec d\u2019autres th\u00e9rapies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9f124d elementor-widget elementor-widget-button\" data-id=\"e9f124d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/nanobiotix.com\/fr\/pipeline\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Notre pipeline<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0692f3f e-flex e-con-boxed e-con e-parent\" data-id=\"0692f3f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-57476ec legal-text no-bot-margin elementor-widget elementor-widget-text-editor\" data-id=\"57476ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9f\u00e9rences: Baskar R, Lee K.A., Yeo R., Yeoh K.W. Cancer and Radiation Therapy: Current Advances and Future Directions. Int J Med Sci 2012; 9(3):193-199. doi:10.7150\/ijms.3635. 2 Alonso-Gonz\u00e1lez C., Gonz\u00e1lez A., Men\u00e9ndez-Men\u00e9ndez J., Mart\u00ednez-Campa C., Cos S. Melatonin as a radio-sensitizer in cancer. Biomedicines. 2020;8(8):247. doi:10.3390\/biomedicines8080247 3 Maggiorella L., Barouch G., Devaux C., Pottier A., et al. Nanoscale radiotherapy with hafnium oxide nanoparticles. Future Oncol. 2012 Sep;8(9):1167-81. doi: 10.2217\/fon.12.96. PMID: 23030491. 4. Zhang P., Marill J., Darmon A., Anesary N.M., Lu B., Paris S. NBTXR3 radiotherapy-activated functionalized hafnium oxide nanoparticles show efficient antitumor effects across a large panel of human cancer models. Int J Nanomedicine. 2021;16:2761-2773. doi:10.2147\/IJN.S301182 5. Yu S., Wang Y., He P., et al. Effective combinations of immunotherapy and radiotherapy for cancer treatment. Front Oncol. 2022;12:809304. doi:10.3389\/fonc.2022.809304 6. Darmon A., Zhang P., Marill J., Anesary N.M., Da Silva J., Paris S. Radiotherapy-activated NBTXR3 nanoparticles modulate cancer cell immunogenicity and TCR repertoire. Cancer Cell Int. 2022;22(1):208. doi:10.1186\/s12935-022-02615-w 7. Fasano M., D\u2019Onofrio I., Belfiore M.P., et al. Head and neck squamous cell carcinoma in elderly patients: role of radiotherapy and chemotherapy. Cancers (Basel). 2022;14(3):472. doi:10.3390\/cancers14030472 8. Bonvalot S., Rutkowski P.L., Thariat J., et al. NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2-3, randomised, controlled trial. Lancet Oncol. 2019;20(8):1148-1159. doi:10.1016\/S1470-2045(19)30326-2<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>NANORADIOENHANCER PLATFORM Enabling a new era of treatment for millions of patients with cancer The vast majority of patients with cancer in need of treatment present with local disease (i.e. a single primary tumor) at diagnosis or have undergone treatment for local disease that has failed. Patients who present with metastatic disease (i.e. tumors that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":28,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-3096","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/pages\/3096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/comments?post=3096"}],"version-history":[{"count":0,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/pages\/3096\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/pages\/28"}],"wp:attachment":[{"href":"https:\/\/nanobiotix.com\/fr\/wp-json\/wp\/v2\/media?parent=3096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}